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CHAF1A

Chromatin assembly factor I CAF-1 is a nuclear complex consisting of p50, p60 CHAF1B, MIM 601245, and p150 CHAF1A subunits that assembles histone tetramers onto replicating DNA in vitro Kaufman et al., 1995.

                                               

Chorionic gonadotropin beta

Choriogonadotropin subunit beta also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorion ...

                                               

Chromosome 19 open reading frame 33

The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental develop ...

                                               

CIRBP

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene. The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, ...

                                               

CKM (gene)

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

                                               

CLC (gene)

Eosinophil lysophospholipase is an enzyme that in humans is encoded by the CLC gene. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophos ...

                                               

CLEC11A

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described b ...

                                               

Cleft lip and palate transmembrane protein 1

Cleft lip and palate transmembrane protein 1 is a protein that in humans is encoded by the CLPTM1 gene. It belongs to a family of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip With or without cleft palate is ...

                                               

Collagen beta(1-o)galactosyltransferase 1

The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the e ...

                                               

Collagen, type V, alpha 3

Collagen alpha-3 chain is a protein that in humans is encoded by the COL5A3 gene. This gene encodes the alpha chain for one of the low abundance fibrillar collagens. The fibrillar collagen molecules are trimers that can consist of one or more typ ...

                                               

Complement component 3

Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.

                                               

COPE (gene)

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from G ...

                                               

COX6B2

Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial el ...

                                               

COX7A1

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene. Cytochrome C oxidase Cox is the terminal with electronic components of the mitochondrial respiratory chain, catalyzes the electron tran ...

                                               

CRB3

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, enc ...

                                               

CRLF1

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival ...

                                               

Cyclin E1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK. Different cyclins exhibi ...

                                               

CYP2A13

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene. This gene encodes a member of cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug meta ...

                                               

CYP2S1

Cytochrome P450 2S1 is a protein that in humans is encoded by the CYP2S1 gene. The gene is located in chromosome 19q13.2 within a cluster including other CYP2 family members such as CYP2A6, CYP2A13, CYP2B6, and CYP2F1.

                                               

CYP4F3

Leukotriene-B omega-hydroxylase 2 is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate from the alternative splicing of a single pre-mRNA precursor molecule, selectio ...

                                               

CYP4F8

This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. ...

                                               

CYP4F11

CYP4F11 is a protein that in humans is encoded by the CYP4F11 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolis ...

                                               

CYP4F12

Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12 gene. This gene encodes a member of cytochrome P450 superfamily of enzymes and is a constituent part of the complex of cytochrome P450 genes on chromosome 19. Cytochrome P ...

                                               

CYP4F22

CYP4F22 is a protein that in humans is encoded by the CYP4F22 gene. This gene encodes a member of cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and sy ...

                                               

CYTH2

Cytohesin-2 CYTH2, formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 2 PSCD2, is a member of the cytohesin family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a ...

                                               

DAPK3

Death-associated protein kinase 3 DAPK3 induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. Unlike most other mammalian genes, mice and ...

                                               

DAZ associated protein 1

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 Deleted in Azoospermia gene clu ...

                                               

DCAF15

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene. DCAF15 forms a complex with CUL4A or CUL4B that the E3 ubiquitin-ligase activity and is responsible for the proteasome degradation of certain proteins.

                                               

DDX39

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene. This gene encodes a member of the dead box protein family. These proteins are characterized by conservative motif ASP-STU-Ala-ASP, dead and presumed RNA he ...

                                               

Deoxyribonuclease ii, lysosomal

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Was characterized by two related alleles, DNASE2*L ...

                                               

Dexh-box helicase 34

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp DEAD, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclea ...

                                               

DHPS

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene. The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic factor of translation initiation 5A. At the f ...

                                               

DLL3

Delta-like 3, also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms have been identified for this gene.

                                               

DNMT1

DNA -methyltransferase 1 is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. DNMT1 forms part of the family of DNA methyltransf ...

                                               

Dock6

Dock6, also known as Zir1 is a large protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins.

                                               

DOT1L

DOT1-like, histone H3K79 methyltransferase, also known as DOT1L, is a protein found in humans, as well as other eukaryotes. The methylation of histone H3 lysine 79 by DOT1L which is a conserved epigenetic mark in many eukaryotic epigenomes, incre ...

                                               

DPP9

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene. This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. Protein, it was shown that the post-Proline amino peptidases dipept ...

                                               

DYRK1B

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isofo ...

                                               

EBI3

This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 s ...

                                               

ECH1

Delta-Delta-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene. This gene encodes a member of the hydratase / isomerase superfamily. The gene product shows high similarity of sequences of enoyl-CoA hydrat ...

                                               

EEF2

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G. This gene encodes a member of the GTP-binding translation elongation factor family. This prot ...

                                               

EGLN2

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is a alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins. Hypoxia-inducible factor HIF is a transcriptional complex invol ...

                                               

EID2

The protein encoded by this gene may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by blocking the histone acetyltransferase activity of p300, class I histone deacetylase, HDACs. The N-terminal portion of ...

                                               

EIF3K

The ~800 kDa eukaryotic initiation factor 3 eIF3 is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation o ...

                                               

ELAV-like protein 1

ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene. The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds CIS-acting AU-rich eleme ...

                                               

ELAV-like protein 3

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene. A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that E ...

                                               

EMP3

Epithelial membrane protein 3 is a trans-membrane signaling molecule that is encoded by the myelin-related gene EMP3. EMP3 is a member of the peripheral myelin protein gene family 22-kDa, which is mainly responsible for the formation of the sheat ...

                                               

Endogenous retrovirus group V member 2, envelope

Many different human endogenous retrovirus HERV families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that ...

                                               

Ephrin A2

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene. This gene encodes a member of the ephrin family. The protein consists of a sequence signal, the receptor-binding spacer region and a hydrophobic region. Eph and Eph-related recep ...

                                               

EPN1

Epsin-1 is a protein that in humans is encoded by the EPN1 gene. EPN1 is an endocytic accessory protein that interacts with EPS15 MIM 600051, alpha-subunit clathrin adaptor AP2 AP2A1, MIM 601026, and clathrin to see MIM 118960, as well as with ot ...