ⓘ Free online encyclopedia. Did you know? page 217




                                               

PSMA2

Proteasome subunit alpha type-2 is a protein that in humans is encoded by the PSMA2 gene. This protein is one of the 17 essential subunits that contributes to the complete assembly of 20S proteasome complex.

                                               

PSMC2

26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the PSMC2 gene This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. Six ...

                                               

PSPH

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also i ...

                                               

PTPN12

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase family PTP. PTPS it is known that signaling molecules th ...

                                               

PTPRN2

Receptor-type tyrosine-protein phosphatase N2 also known as islet cell autoantigen-related protein and phogrin is an enzyme that in humans is encoded by the PTPRN2 gene. PTPRN and PTPRN2 are both found to be major autoantigens associated with ins ...

                                               

PTPRZ1

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. A ...

                                               

PURB

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene. This gene product is a sequence-specific, single-stranded DNA-binding proteins. It binds preferentially to one direction of the Purine-rich elemen ...

                                               

RAC1

Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out di ...

                                               

RALA

Ras-related protein Ral-A is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular swit ...

                                               

RAMP3

Receptor activity modifying protein 3, also known as RAMP3, is a human gene. The protein encoded by this gene is a member of the ramp family of single transmembrane domain protein called the calcitonin receptor activity protein modifications ramp ...

                                               

RAPGEF5

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene. The members of the RAS subfamily to see the CRAS, MIM 190020 from GTPase function in signal transduction as GTR / GDP-regulated switches that cyc ...

                                               

RBM28

RNA-binding protein 28 is a protein that in humans is encoded by the RBM28 gene. It is a nucleolar component of the spliceosomal ribonucleoprotein complexes.

                                               

RCP9

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene. This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular camp lev ...

                                               

RFC2

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen PCNA and replication factor C RFC. RFC, also called activator 1, is a protein complex con ...

                                               

RHEB

RHEB also known Ras homolog enriched in brain is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle. RHEB is a recently discov ...

                                               

RNF32

RING finger protein 32 is a protein that in humans is encoded by the RNF32 gene. The protein encoded by this gene contains two ring finger motifs. Ring finger motifs are present in a variety of functionally distinct proteins and known to be invol ...

                                               

RNF216

E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene. This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine / threonine protein kinase, receptor interaction pr ...

                                               

RP9

The removal of introns from nuclear pre-mRNAs occurs on a complex called a spliceosome, which is made up of 4 small nuclear ribonucleoprotein snRNP particles and an undefined number of transiently associated splicing factors. The exact role of PA ...

                                               

SCIN

Scinderin is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaros laboratory at the University of Ottawa, Canada. Secretory tissues a ...

                                               

SDK1

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and int ...

                                               

SEC61G

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum ER membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ...

                                               

SEMA3A

The SEMA3A gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type immunoglobulin-like domain, a PSI domain and a Sema domain. This secreted Sema3A protein can function as either a chemorepulsive agent, inhibiting ...

                                               

Semaphorin 3E

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin Sema domain and a PSI domain found in plexins, semaphorins and integrins in the N-terminal extracellular portion. Based on sequence a ...

                                               

SEPT7

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, con ...

                                               

SEPT14

SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions.

                                               

Serrate RNA effector molecule homolog

Serrate RNA effector molecule homolog also known as arsenite-resistance protein 2 is a protein that in humans is encoded by the SRRT gene. SRRT gene product plays a role in RNA-mediated gene silencing through RNA-microRNA. Regardless of its effec ...

                                               

SFRP4

Secreted frizzled-related protein 4 SFRP4 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SF ...

                                               

SGCE

Epsilon-sarcoglycan is a protein that in humans is encoded by the SGCE gene. Sheet gene encodes the Epsilon member of sarcoglycan family, transmembrane components of the dystrophin-glycoprotein complex that connects the cytoskeleton to the extrac ...

                                               

SKAP2

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various ...

                                               

SLC12A9

Solute carrier family 12 member 9, also known as cation-chloride cotransporter 6 or cation-chloride cotransporter-interacting protein 1, is a protein that in humans is encoded by the SLC12A9 gene.

                                               

SMARCD3

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.

                                               

SND1

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 is a protein that in humans is encoded by the SND1 gene. SND1 is a main component of RISC complex and plays an important r ...

                                               

Sorting nexin 10

This gene encodes a member of the sorting nexin family. Members of this family contain a phox PX domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region ...

                                               

SOSTDC1

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein BMP antagonist. Specifically, it directly associates ...

                                               

SPAM1

Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene. Hyaluronidase decreases hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basal membranes. Six members of the hyaluronidase family ar ...

                                               

SSC4D

The scavenger receptor cysteine-rich SRCR superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adap ...

                                               

ST7

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene. ST7 orthologs have been identified in all mammals for which complete genome data are available.

                                               

STAG3 (gene)

Stromal antigen 3 is a protein that in humans is encoded by the STAG3 gene. STAG3 protein is a component of a cohesin complex that regulates the separation of sister chromatids specifically during meiosis. STAG3 appears to participate in sister-c ...

                                               

STARD3NL

MENTHO or STARD3 N-terminal like protein is an integral membrane protein of unknown function. As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also ...

                                               

STEAP1

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. This gene is expressed primarily in prostate tissue and is upregulated in several cancer cell lines. The gene product is a predicted six transmembrane protein and ...

                                               

STEAP2

Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene. This gene is a member of the cool family and encodes a multi-pass membrane protein that is localized in the Golgi complex, plasma membrane and vesicular tubular st ...

                                               

STEAP4

The protein encoded by this gene belongs to the STEAP six transmembrane epithelial antigen of prostate family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1 ...

                                               

STK17A

This gene is a member of the death-associated protein DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.

                                               

STX1A

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. ...

                                               

SUMF2

Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene. The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine FGly. The FGly residue is posttranslationally gene ...

                                               

Syncytin-1

Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene. Syncytin-1 is a cell-cell fusion protein whose function is best characterized in placental development. The placenta in turn aids ...

                                               

TAF6

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID TFIID, which binds to the core promoter to position the polymerase pr ...

                                               

TARP (gene)

TCR gamma alternate reading frame protein, also known as TARP, is a human gene. In some non-lymphoid tissues, the unrearranged T cell receptor gamma TRG locus is expressed. The resulting transcript contains a subset of the TRG gene segments and i ...

                                               

TBRG4

Transforming growth factor beta regulator 4, also known as cell cycle progression restoration protein 2 and FAST kinase domain-containing protein 4, is a protein that in humans is encoded by the TBRG4 gene on chromosome 7. This protein is part of ...

                                               

Tectonin beta-propeller repeat containing 1

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy