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Laminin, gamma 2

Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene. Laminins a family of extracellular matrix glycoproteins, are the major noncollagenous component of basement membrane. They were involved in a wide range of biologic ...

                                               

Latrophilin

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin. This conser ...

                                               

Latrophilin 2

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene. This gene encodes a member of the latrophilin subfamily of G-coupled protein receptors GPCR. Latrophilins may function in cell adhesion and signal transduction. In animal ex ...

                                               

Left-right determination factor 1

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three diff ...

                                               

Leiomodin 1

The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expr ...

                                               

Leptin receptor

Leptin receptor, also known as LEP-or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the LEPR gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295. Its ...

                                               

LGTN

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene. This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

                                               

LHX4

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene. This gene encodes a member a large protein family which contains the lim domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a ...

                                               

Ligand-dependent nuclear receptor-interacting factor 1

Ligand-dependent nuclear receptor-interacting factor 1 also known as receptor-interacting factor 1 is a protein that in humans is encoded by the LRIF1 gene.

                                               

Lim homeobox 9

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The ...

                                               

LIN28

Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. LIN28 encodes an RNA-binding protein, which binds to and enhances the translation of IGF-2 insulin-like growth factor 2 mRNA. Lin28 binds to let-7 pre-miRNA and blocks the ...

                                               

LMO4

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene. Lim domain only 4 is a cysteine-rich, two lim domain-containing protein that may play a role as a transcription regulator or possibly an oncogene. Its m ...

                                               

LMX1A

Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promo ...

                                               

Low-density lipoprotein receptor adapter protein 1

Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene. The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding PTB domain. PTB domain was found to in ...

                                               

LRRC7

Found to be densely associated to the postsynaptic density PSD, it has been characterised as a 188 kDa originally thought to be 180 kDa, hence nomenclature, 1495 residues long, brain-specific protein containing 16 leucine-rich repeats LRRs within ...

                                               

LRRC8D

Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8E, is a subunit of the heterom ...

                                               

LRRC40

LRRC40 is conserved throughout all of its orthologs. The entire protein is highly conserved in mammals, while conservation is high within the leucine rich repeats in the rest of the orthologs. Orthologs were found all the way back to the scarlet ...

                                               

LRRN2

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene. The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and highly expressed in malignan ...

                                               

LYPLAL1

Lysophospholipase-like 1 is a protein in humans that is encoded by the LYPLAL1 gene. The protein is a α/β-hydrolase of uncharacterized metabolic function. Genome-wide association studies in humans have linked the gene to fat distribution and wais ...

                                               

MAD2L2

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.

                                               

MAGOH

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene. Drosophila that have mutations in the gene Mago Nashi grandchildless to produce progeny with defects in the collection of material and development of the germ li ...

                                               

Major facilitator superfamily domain containing 14a

Major facilitator superfamily domain containing 14A is a protein that in humans is encoded by the MFSD14A gene. MFSD14A is an atypical solute carrier of MFS type. HGNC:23363 Cluster MFSD14A in AMTF1, along with MFSD9, MFSD10 and MFSD14B.

                                               

MAPKAPK2

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes includi ...

                                               

MARCKSL1

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate MARCKS family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the for ...

                                               

MASP2 (protein)

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 is an enzyme that in humans is encoded by the MASP2 gene.

                                               

MAST2

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene. The protein encoded by this gene controls TRAF6 and NF-kappaB activity.

                                               

MCL1

The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product isoform 1 enhances cell survival by inhib ...

                                               

MDM4

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is l ...

                                               

MECR

The MECR gene is located on the 1st chromosome, with its specific location being 1p35.3. The gene contains 15 exons. MECR encodes a 21.2 kDa protein that is composed of 189 amino acids, 10 peptides have been observed through mass spectrometry data.

                                               

MED8

This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 ...

                                               

MFAP2

Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene. Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited c ...

                                               

MFN2

Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. Mitofusins are GTPases embedded in the outer membrane of the mitochondria. In mammals MFN1 and MFN2 are essential for mitochondrial fusion. In addition to the mitofusins, OPA1 r ...

                                               

MFSD2

Major facilitator superfamily domain-containing protein 2 -- also known as sodium-dependent lysophosphatidylcholine symporter 1 -- is a protein that in humans is encoded by the MFSD2A gene. MFSD2A is a membrane transport protein that is expressed ...

                                               

MGST3

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene. Membrane-associated proteins in the MAPEG family of eicosanoids and glutathione metabolism consists of six human proteins, several of which are invol ...

                                               

MiR-214

miR-214 is a vertebrate-specific family of microRNA precursors. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

                                               

Mitochondrial pyruvate carrier 2

Mitochondrial pyruvate carrier 2 also known as brain protein 44 is a protein that in humans is encoded by the MPC2 gene. It is part of the Mitochondrial Pyruvate Carrier protein family. This protein is involved in transport of pyruvate across the ...

                                               

Mitogen-activated protein kinase 6

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor VEGF expression. Alternati ...

                                               

MMACHC

The C-terminal region of the product of the MMACHC gene is similar to TonB, a bacterial protein involved in energy transduction for cobalamin uptake. The MMACHC gene product catalyzes the decyanation of cyanocobalamin as well as the dealkylation ...

                                               

MMEL1

The protein encoded by this gene is a member of the neutral endopeptidase NEP or membrane metallo-endopeptidase MME family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis ...

                                               

MMP23B

This gene MMP23B encodes a member of the matrix metalloproteinase MMP family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase MMP family are involved in the breakdown of extracellular matrix in ...

                                               

MRPL55

39S ribosomal protein L55, mitochondrial is a protein that in humans is encoded by the MRPL55 gene. Mitochondrial ribosomal protein of mammals is encoded by nuclear genes and help in protein synthesis in the mitochondria. Mitoribosomes mitochondr ...

                                               

MSH4

The MSH4 and MSH5 proteins form a hetero-oligomeric structure heterodimer in yeast and humans. In the yeast Saccharomyces cerevisiae MSH4 and MSH5 act specifically to facilitate crossovers between homologous chromosomes during meiosis. The MSH4/M ...

                                               

MTX1

The metaxin gene, which encodes a protein located on the outer membrane of mitochondria, is a component of the mitochondrial protein translocation apparatus.

                                               

MUL1

Mitochondrial E3 ubiquitin protein ligase 1 is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through mult ...

                                               

Muscarinic acetylcholine receptor M3

The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M 3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3. M 3 muscarinic receptors are found in many places in the bod ...

                                               

MUTYH

MUTYH is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbone at sites where adenine ...

                                               

Myocilin

Myocilin, trabecular meshwork inducible glucocorticoid response, also known as MYOC, is a protein which in humans is encoded by the MYOC gene. Mutations in MYOC are a major cause of glaucoma.

                                               

NBPF19

Neuroblastoma breakpoint family member 19, or NBPF19, is a protein that in humans is encoded by the NBPF19 gene. This protein is included in the neuroblastoma breakpoint family of proteins.

                                               

Netrin G1

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene. Netrin G1 NTNG1 refers to a conserved family of proteins that act as Axon guidance signals in the nervous system of vertebrate development Nakashiba et al., 2000.

                                               

Neutrophil cytosolic factor 2

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neut ...